【 SCIE 】 Tyrphostin A9 improves blastocyst development in porcine embryos through induction of dynamin-related protein 1-dependent mitochondrial fission > 학술지 논문

【 TITLE 】Tyrphostin A9 improves blastocyst development in porcine embryos through induction of dynamin-related protein 1-dependent mitochondrial fission

【 JOURNAL 】Mitochondrion

​【 NAME 】Jae-HyunAhn, Hyo-Jin Park, Jin-Woo Kim, Jae-Young Park. Soo-Yong Park, Seul-Gi Yang, Chang-Hyun Kim, Seung-Bin Yoon, Sun-Uk Kim, Kyu-Tae Chang and Deog-Bon Koo

【 PUBLISHED 】 Jul 2017​

【 ISSN 】1567-7249

【 DOI 】10.1016/j.mito.2017.05.008

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​【 ABSTRACT 】

​ Mitochondrial dynamics are associated with the development of porcine embryos. However, little is known about the effects of mitochondrial dynamics-related genes (Drp1 and pDrp1-Ser616) on early porcine embryo development. Here, we investigated the effect of Drp1-dependent mitochondrial fission signaling on the development of porcine embryos using the mitochondrial fission inducer, tyrphostin A9 (TA9). We determined that TA9 (1 μM) treated embryos were increased the mitochondrial functions, blastocyst development rate and quality, as well as decreased mitochondria-specific superoxide and mitochondrial apoptosis. Thus, TA9-induced appropriate mitochondrial fission improved the developmental competence via maintenance of a balance in mitochondrial dynamics in porcine embryo.

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【 KEYWORDS 】Tryphostin A9 (TA9), Mitochondrial fission, Drp1, Mitochondrial function, Porcine embryo